Which drugs had high first pass effect_____________?

Related Mcqs:

1. Which of the following drugs when used for prolonged period in the maintenance treatment of tonic-clonic seizures can lead to increased metabolism of warfarin like drugs?

   A. Phenobarbital.
   B. Meprobamate
   C. Chlordiazepoxide
   D. Triazolam
   E. Zolpidum

   Submitted by: Dr.Tassawer-e-Meran

2. Drugs exhibiting first pass metabolism are all EXCEPT one______________?

   A. Morphine
   B. Nitroglycerine
   C. Propranolol
   D. Salicylates

3. Drugs showing zero order kinetics of elimination_____________?

   A. Are more common than first order kinetics
   B. Decrease in concentration exponentially with time
   C. Have a half – life independent of dose
   D. Show a plot of drug concentration versus time that is linear

4. Teratogenicity results when drugs are given during____________?

   A. First trimester
   B. Second trimester
   C. Third trimester
   D. Soon after birth

5. Majority of drugs are transported across the membrane by____________?

   A. Passive diffusion
   B. Active transport
   C. Facilitated trasnsport
   D. Filtration

6. All of the following drugs are non depolarizing neuromuscular blocking agents except_______________?

   A. D-tubocurarine
   B. Gallamine triethiodide
   C. Pancuronium bromide
   D. Succinylcholine

7. Which of the following drugs undergoes “Hoffmann elimination” ?

   A. d-tubecurarine
   B. Acetycholine
   C. Atracurium
   D. Acetazolamide

8. Drugs producing ototoxicity and Nephro toxicity are______________?

   A. Tetracyclines
   B. Aminoglycosides
   C. Quinalones
   D. Macrolides

9. All of the following drugs are useful in treatment of hypertension except______________?

   A. Ephedrine
   B. Reserpine
   C. Methyldopa
   D. Thiazole diuretics

10. Which one of the following drugs has been shown to offer protection from gastric aspiration syndrome in a patient with symptoms of reflex ?

    A. Ondansetron
    B. Metoclopramide
    C. Sodium citrate
    D. Atropine