In sickle cell anaemia there is_____________?

Related Mcqs:

1. Heterozygous sickle cell anaemia gives protection against______________?

   A. G6PD
   B. Malaria
   C. Thalassemia
   D. Dengue fever

2. In sickle cell anemia there is substitution of_________________?

   A. Valine for glutamic acid at the sixth position of beta chain
   B. Phenylalanine for glutamic acid
   C. Tyrosine for valine at the 6th position at beta chain
   D. All of the above

3. Sickle cell anemia precipitates when______________?

   A. Oxygen tension goes down
   B. Increased viscosity of blood
   C. There is dehydration
   D. All of the above

4. Glutamine replaced by valine in sckle cell anaemia is characterized________________?

   A. Non Sense mutation of beta chain
   B. Missense mutation of beta chain
   C. Degradation of beta chain
   D. Deletion of beta chain

5. In megaloblastic anaemia the cells are___________________?

   A. Macrocytic hyperchromic
   B. Macrocytic hypochromic
   C. Macrocytic normochromic
   D. None of the above

6. Pernicious anaemia is associated with the deficiency of________________?

   A. Folic acid
   B. Vitamin B1
   C. Vitamin B6
   D. Vitamin B12

7. A 14 year old boy complains with gingival bleeding oral ulcers, anaemia with hepatomegaly but no lymphadenopathy, total eukocyte count of one-lakh cells per mm3 is suffering from________________?

   A. Acute myeloid leukemia
   B. Chronic monocytic leukemia
   C. Chronic lymphoblastic leukemia
   D. Chronic myeloid leukemia

8. A 3-year old child presented with progressive anaemia, jaundice & failure to thrive. O/E: pallor, splenomegaly are seen Peripheral smear showed normoblasts and small round intensely stained red cells. The likely diagnosis is________________?

   A. Here ditary spherocytosis
   B. Thalassaemia
   C. Sickle cell anaemia
   D. Vitamin B12 deficiency anaemia

9. Megaloblastic anaemia is caused by_________________?

   A. Dog tapeworm
   B. Hookworm
   C. Fish tapeworm
   D. Threadworm

10. megaloblastic anaemia occurs due to________________?

    A. Iron deficiency
    B. Folate deficiency
    C. Vitamin C deficiency
    D. Protein deficiency