A. Over hunting is perhaps the most obvious direct cause of extinction in animals, as it has affected several large and well-known species
B. Genetic diversity as represented by genetic differences between discrete populations with wild species, is liable to reduction as result of the same factors affecting species
C. A major, though at present largely unpredictable, change in natural environments is likely to occur within the next century as a result of large-scale changes in global climate and weather patterns
D. All of the above
The correct answer to the question: "The causes of loss of biological diversity are:" is "All of the above".